[Federal Register Volume 67, Number 106 (Monday, June 3, 2002)]
[Notices]
[Pages 38280-38281]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 02-13767]
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DEPARTMENT OF HEALTH AND HUMAN SERVICES
Agency for Toxic Substances and Disease Registry
[ATSDR-182]
Availability of Draft Guidance Manual and Draft Interaction
Profiles
AGENCY: Agency for Toxic Substances and Disease Registry (ATSDR),
Department of Health and Human Services (HHS).
ACTION: Notice of availability.
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SUMMARY: This notice announces the availability of a draft guidance
manual and six draft interaction profiles prepared by ATSDR for review
and comment.
DATES: To ensure consideration, comments on these draft documents must
be received on or before September 2, 2002. Comments received after the
close of the public comment period will be considered at the discretion
of ATSDR based upon what is deemed to be in the best interest of the
general public.
ADDRESSES: Requests for copies of the draft interaction profiles should
be sent to the attention of Ms. Franchetta Stephens, Division of
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop
E-29, 1600 Clifton Road, NE, Atlanta, Georgia 30333.
Requests for the draft interaction profiles must be in writing, and
must specifically identify the interaction profile(s) that you wish to
receive. The documents will be primarily available in electronic Adobe
Acrobat (pdf) files. If you do not have a computer, you can ask for a
hard copy. ATSDR reserves the right to provide only one copy of each
profile requested, free of charge. In case of extended distribution
delays, requestors will be notified.
Interaction profiles and the guidance manual will also be available
on ATSDR's Web site at http://www.atsdr.cdc.gov.
Written comments and other data submitted in response to this
notice and the draft interaction profiles or draft guidance document
should bear the docket control number ATSDR-182. Send one copy of all
comments and three copies of all supporting documents to Dr. Hana Pohl,
ATSDR, Division of Toxicology, Mailstop E-29, 1600 Clifton Road,
Atlanta, Georgia 30333 by the end of the comment period. Because all
public comments regarding ATSDR interaction profiles and the guidance
manual are available for public inspection after they are published in
final, no confidential business information or other confidential
information should be submitted in response to this notice.
FOR FURTHER INFORMATION CONTACT: Ms. Franchetta Stephens, Division of
Toxicology, Agency for Toxic Substances and Disease Registry, Mailstop
E-29, 1600 Clifton Road, NE, Atlanta, Georgia 30333, telephone (888)
422-8737 or (404) 498-0720.
SUPPLEMENTARY INFORMATION: The Comprehensive Environmental Response,
Compensation, and Liability Act of 1980 (CERCLA) mandates that the
Agency for Toxic Substances and Disease Registry (ATSDR) shall assess
whether adequate information on health effects is available for the
priority hazardous substances. Where such information is not available
or under development, ATSDR shall, in cooperation with the National
Toxicology Program, initiate a program of research to determine these
health effects. The Act further directs that where feasible, ATSDR
shall develop methods to determine the health effects of substances in
combination with other substances with which they are commonly found.
The Food Quality Protection Act (FQPA) of 1996 requires that factors to
be considered in establishing, modifying, or revoking tolerances for
pesticide chemical residues shall include the available information
concerning the cumulative effects of substances that have a common
mechanism of toxicity, and combined exposure levels to the substance
and other related substances. The FQPA requires that the Administrator
of the Environmental Protection Agency consult with the Secretary of
the Department of Health and Human Services (which includes ATSDR) in
implementing some of the provisions of the act.
To carry out these legislative mandates, ATSDR has developed a
chemical mixtures program. As part of
[[Page 38281]]
the mixtures program, ATSDR developed a guidance manual that outlines
the latest methods for mixtures health assessment. In addition, a
series of documents called interaction profiles are being developed for
certain priority mixtures that are of special concern to ATSDR. The
purpose of an interaction profile is to evaluate data on the toxicology
of the ``whole'' priority mixture (if available) and on the joint toxic
action of the chemicals in the mixture in order to recommend approaches
for the exposure-based assessment of the potential hazard to public
health.
Although key studies for each of the mixtures were considered
during the profile development process, this Federal Register notice
seeks to solicit any additional studies, particularly unpublished data
and ongoing studies, which will be evaluated for possible addition to
the profiles now or in the future.
The following draft documents will be available to the public on or
about, June 1, 2002.
Document 1
Guidance manual for the assessment of joint toxic action of
chemical mixtures.
Document 2
Interaction profiles for persistent chemicals found in fish.
Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene,
dichlorodiphenyl dichloroethane (p,p'-DDE), methyl mercury, and
polychlorinated biphenyls (PCBs).
Document 3
Interaction profiles for persistent chemicals found in breast milk.
Chlorinated dibenzo-p-dioxins (CDDs), hexachlorobenzene,
dichlorodiphenyl dichloroethane (p,p'-DDE), methyl mercury, and
polychlorinated biphenyls (PCBs).
Document 4
Interaction profile for 1,1,1-trichloroethane, 1,1-dichloroethane,
trichloroethylene, and tetrachloroethylene.
Document 5
Interaction profile for benzene, ethylbenzene, toluene, and xylenes
(BTEX).
Document 6
Interaction profile for arsenic, cadmium, chromium, and lead.
Document 7
Interaction profile for copper, lead, manganese, and zinc.
All documents issued as ``Drafts for Public Comment'' represent
ATSDR's best efforts to provide important toxicological information on
interactions of priority hazardous substances. We are seeking public
comments and additional information which may be used to supplement
these documents. ATSDR remains committed to providing a public comment
period for these documents as a means to best serve public health and
our clients.
Dated: May 24, 2002.
Georgi Jones,
Director, Office of Policy and External Affairs, Agency for Toxic
Substances and Disease Registry.
[FR Doc. 02-13767 Filed 5-31-02; 8:45 am]
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